Category:
Non-Human Primate (NHP) related Antibody Products
BAI1 Polyclonal Antibody (NHP-AB310)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing rabbit against a peptide located in the N-Terminal domain of BAI1 (Human). It is used only in in vitro assays.
Introduction:
BAI1 is a phosphatidylserine receptor that enhances the engulfment of apoptotic cells, likely to be a potent inhibitor of angiogenesis in brain, and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. BAI1 may function in cell adhesion and signal transduction in the brain. Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. As such, tumors obtain blood supply for their growth, are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one functional p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI1 and BAI3, which have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas. Diseases associated with BAI1 include Glioblastoma.
Conjugate:
None
Applications:
ELISA; IHC
Host Species:
Rabbit
Species Reactivity:
Bovine; Gibbon; Gorilla; Human; Monkey
Immunogen:
A peptide located in the N-Terminal domain of BAI1 (Human)
Purification:
Immunoaffinity Chromatography
Format:
Liquid
Concentration:
0.7 mg/mL
Buffer:
PBS, 0.1% sodium azide.
Storage:
Short term: 4˚C. Long term: Store at -20˚C.
Clonality:
Polyclonal
Alternative Names:
Adhesion G protein-coupled receptor B1; Brain-specific angiogenesis inhibitor 1; FLJ41988; Vasculostatin-120; Vasculostatin-40; Vstat-40; Vstat120; Vstat40
Entrez Gene ID:
575
- BAI1 Polyclonal Antibody (NHP-AB310) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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