Category:
Non-Human Primate (NHP) related Antibody Products
Anti-PD1 Recombinant Antibody (R4LA) (NHP-AB070)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
The antibody based on anti-human PD-1 recognizes PD-1 receptor. This product is a rhesus recombinant antibody (rhesus/human chimeric) applied for in vivo administration.
Introduction:
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
Conjugate:
None
Antibody Isotype:
IgG4
Applications:
In Vivo; Blocking
Species Reactivity:
Human; Rhesus
Purification:
Confirmed by HPLC
Storage:
Stable at 4 °C. Do not freeze.
Target:
PD1
Clone:
R4LA
Alternative Names:
CD279; hPD1; mPD-1; Programmed cell death protein 1; Protein PD-1; Protein PD1; sCD279; soluble CD279
- Anti-PD1 Recombinant Antibody (R4LA) (NHP-AB070) Data Sheet: Detailed information. datasheet
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