IGFBP5 Polyclonal Antibody (NHP-AB384)

• This product is an antibody that was generated by immunizing rabbit against synthetic peptide sequence from human IGFBP5 amino acids 192-206. It is used only in in vitro assays.

Detailed Product Description

• Introduction: The insulin-like growth factor-binding proteins, or IGFBPs, are a family of homologous proteins that have co-evolved with the IGFs. They serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, as well as their concentration and distribution in the extracellular environment. In addition, the IGFBPs appear to have biological activity independent of the IGFs. Seven IGFBPs have thus far been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. For instance, IGFBP1 is negatively regulated by insulin production. The IGFBP1 gene is expressed at a high level during fetal liver development and in response to nutritional changes and diabetes. It has been suggested that IGFBP2 functions as chaperone, escorting IGFs to their target tissues. It is expressed in several human tissues including fetal eye and fetal brain. IGFBP3 is the most abundant IGFBP and is complexed with roughly 80% of the serum IGFs. Both IGFBP3 and IGFBP4 are released by dermal fibroblasts in response to incision injury. IGFBP5 is secreted by myoblasts and may play a key role in muscle differentiation.
• Conjugate: None
• Antibody Isotype: IgG
• Applications: IHC; WB

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Bat; Bovine; Dog; Gibbon; Goat; Gorilla; Hamster; Horse; Human; Monkey; Pig; Rabbit
• Immunogen: Synthetic peptide sequence from human IGFBP5 amino acids 192-206

Product Property

• Purification: Affinity Purified
• Format: Liquid
• Buffer: TBS pH 7.4, containing 50% glycerol, 0.5 mg/ml BSA, and 0.02% sodium azide
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Alternative Names: IBP 5; IBP-5; IGF BP5; IGF-bindingprotein 5; IGFBP; IGFBP 5; IGFBP-5; Insulin like growth factor binding protein; insulin-like growth factor binding protein 5; Insulin-like growth factor-binding protein 5
• Entrez Gene ID: 3488