Category:
Non-Human Primate (NHP) related Antibody Products
CD11b Monoclonal Antibody (kay) (NHP-AB114)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing rat against C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes. It is used only in in vitro assays.
Introduction:
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.
Conjugate:
None
Antibody Isotype:
IgG2b
Applications:
ELISA; Flow Cytometry; ICC; IHC-Fr
Host Species:
Rat
Species Reactivity:
Baboon; Human; Mouse; Rabbit
Immunogen:
C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes
Format:
Liquid
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Storage:
Store at 4⁰C.
Target:
CD11b
Clone:
kay
Clonality:
Monoclonal
Alternative Names:
Integrin alphaM, Mac-1alpha, Mac-1, Mo1, CR3, C3biR
Entrez Gene ID:
16409
- CD11b Monoclonal Antibody (kay) (NHP-AB114) Data Sheet: Detailed information. datasheet
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Your research is unique, and we understand that standard products may not always fit. Our team of experts specializes in custom NHP sample collections. We can design a tailored protocol to meet your specific research requirements, including samples with unique anticoagulant types, customized volumes, or from specific disease models.
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For research use only. Not intended for any clinical use.
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