Category:
Non-Human Primate (NHP) related Antibody Products
AOF2 Polyclonal Antibody (NHP-AB303)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing rabbit against a portion of amino acids 100-150 of human LSD1. It is used only in in vitro assays.
Introduction:
AOF2 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. AOF2 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. AOF2 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distinctive facial features.
Conjugate:
None
Applications:
IHC; WB
Host Species:
Rabbit
Species Reactivity:
Dog; Human; Macaque; Monkey; Mouse; Rat; Zebrafish
Immunogen:
A portion of amino acids 100-150 of human LSD1
Purification:
Immunoaffinity Chromatography
Format:
Liquid
Concentration:
0.5 mg/mL
Buffer:
PBS, 0.2% gelatin, 0.05% sodium azide.
Storage:
Short term: 4˚C. Long term: Store at -20˚C.
Clonality:
Polyclonal
Alternative Names:
[histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A; amine oxidase (flavin containing) domain 2; BRAF35-HDAC complex protein BHC110; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; Flavin-containing amine oxidase domain-containing protein 2; lysine (K)-specific demethylase 1; lysine (K)-specific demethylase 1A; lysine-specific histone demethylase 1; Lysine-specific histone demethylase 1A; neuroprotective protein 3; RP1-184J9.1
Entrez Gene ID:
23028
- AOF2 Polyclonal Antibody (NHP-AB303) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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