SCNN1B Polyclonal Antibody (NHP-AB449)

• This product is an antibody that was generated by immunizing rabbit against recombinant fusion protein containing a sequence corresponding to amino acids 406-640 of human SCNN1B (NP_000327.2). It is used only in in vitro assays.

Detailed Product Description

• Introduction: SCNN1B mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. Defects in SCNN1B are a cause of autosomal recessive pseudohypoaldosteronism type 1 (PHA1). PHA1 is a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal recessive form that is severe, and the dominant form which is more milder and due to defects in mineralocorticoid receptor. Autosomal recessive PHA1 is characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatraemia, hyperkalaemia, metabolic acidosis, failure to thrive and weight loss.
• Conjugate: None
• Antibody Isotype: IgG
• Applications: WB

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Human; Monkey; Mouse
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 406-640 of human SCNN1B (NP_000327.2)

Product Property

• Purification: Affinity purification
• Format: Liquid
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Storage: Store at -20⁰C. Avoid freez-thaw cycles.

Target Information

• Clonality: Polyclonal
• Related Disease: Defects in SCNN1B are a cause of Liddle syndrome. It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel.
• Alternative Names: Amiloride-sensitive sodium channel subunit beta; amiloride-sensitive sodium channel subunit beta 1; amiloride-sensitive sodium channel subunit beta-like protein; Beta ENaC; Beta-ENaC; Beta-NaCH; ENaC beta; Epithelial Na(+) channel subunit beta; epithelial sodium channel beta-2 subunit; epithelial sodium channel beta-3 subunit; epithelial sodium channel, nonvoltage-gated 1, beta; nasal epithelial sodium channel beta subunit; Nonvoltage-gated sodium channel 1 subunit beta; SCNEB; SCNN 1B; sodium channel, non voltage gated 1 beta subunit; sodium channel, non-voltage-gated 1, beta subunit; sodium channel, nonvoltage-gated 1, beta; sodium channel, nonvoltage-gated, type I, beta
• Entrez Gene ID: 6338