Category:
Non-Human Primate (NHP) related Antibody Products
ARHGEF7 Polyclonal Antibody (NHP-AB306)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing rabbit against recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ARHGEF7 (NP_001106984.1). It is used only in in vitro assays.
Introduction:
The serine/threonine kinase, p21 activated kinase (PAK), is a downstream effector of the small GTPases Cdc42 and Rac. PAK associates with Nck, the p85 and p110 subunits of PI3-kinase and PIX (PAK-interacting exchange factor) in a focal complex. The binding of PIX is necessary for the localization and activation of PAK in the Cdc42 to Rac signaling pathway, and this binding occurs through the high affinity of the N-terminal SH3 domain of PIX for a conserved proline rich PAK sequence. PIX exists as two isoforms, alpha and beta, and both are highly expressed in heart, muscle and thymus tissues of human and rat. alphaPIX is phosphorylated via PDGF and EphB2 receptor signaling pathways or through association with PI3-kinase. The alphaPIX isoform predominantly acts as a guanine nucleotide exchange factor (GEF) on Rac, which may mediate lamellipodia formation.
Conjugate:
None
Applications:
IF; WB
Host Species:
Rabbit
Species Reactivity:
Human; Monkey; Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ARHGEF7 (NP_001106984.1).
Purification:
Affinity purification
Format:
Liquid
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at -20⁰C. Avoid freeze-thaw cycles.
Clonality:
Polyclonal
Alternative Names:
Beta-Pix; COOL-1; p85; p85SPR; PAK-interacting exchange factor beta; Pak3 binding protein; beta PIX; Rho guanine nucleotide exchange factor (GEF) 7; Rho guanine nucleotide exchange factor 7; SH3 domain-containing proline-rich protein
Entrez Gene ID:
8874
- ARHGEF7 Polyclonal Antibody (NHP-AB306) Data Sheet: Detailed information. datasheet
There are currently no customer reviews or questions for ARHGEF7 Polyclonal Antibody (NHP-AB306). Click the button below to contact us or submit your feedback about this product.
Your research is unique, and we understand that standard products may not always fit. Our team of experts specializes in custom NHP sample collections. We can design a tailored protocol to meet your specific research requirements, including samples with unique anticoagulant types, customized volumes, or from specific disease models.
You may also be interested in…
Online Inquiry
For research use only. Not intended for any clinical use.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.