DDX3X Monolonal Antibody (Y6R3) (NHP-AB211)

• This product is an antibody that was generated by immunizing mouse against recombinant protein of human DDX3X. It is used only in in vitro assays.

Detailed Product Description

• Introduction: The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants.
• Conjugate: None
• Antibody Isotype: IgG
• Applications: ICC; IP; WB

Technical Specifications

• Host Species: Mouse
• Species Reactivity: Human; Monkey; Mouse; Rat
• Immunogen: Recombinant protein of human DDX3X

Product Property

• Purification: Affinity purification
• Format: Liquid
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Storage: Store at -20⁰C. Avoid freez-thaw cycles.

Target Information

• Target: DDX3X
• Clone: Y6R3
• Clonality: Monoclonal
• Alternative Names: ATP-dependent RNA helicase DDX3X; CAP-Rf; DBX; DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD box protein 3, X-chromosomal; DEAD box, X isoform; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3; DEAD/H box-3; Helicase-like protein 2; HLP2
• Entrez Gene ID: 1654