Category:
Non-Human Primate (NHP) related Antibody Products
BUB1B Polyclonal Antibody (NHP-AB312)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing rabbit against recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human BUB1B (NP_001202.4). It is used only in in vitro assays.
Introduction:
BUBR1 is a member of the Ser/Thr protein kinase family. It is a component of the mitotic checkpoint that delays anaphase until all chromosome are properly attached to the mitotic spindle. Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.
Conjugate:
None
Antibody Isotype:
IgG
Applications:
IF; IHC; WB
Host Species:
Rabbit
Species Reactivity:
Human; Monkey; Mouse; Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human BUB1B (NP_001202.4).
Purification:
Affinity purification
Format:
Liquid
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at -20⁰C. Avoid freeze-thaw cycles.
Clonality:
Polyclonal
Alternative Names:
BUB1B, mitotic checkpoint serine/threonine kinase; budding uninhibited by benzimidazoles 1 homolog beta; hBub1; hBUBR1; MAD3/BUB1-related protein kinase; Mitotic checkpoint kinase MAD3L; Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; Protein SSK1
Entrez Gene ID:
701
- BUB1B Polyclonal Antibody (NHP-AB312) Data Sheet: Detailed information. datasheet
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