Category:
Non-Human Primate (NHP) related Antibody Products
CD107a Monoclonal Antibody (B4A3), PE-Cy5 (NHP-AB093)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
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Customer Reviews
This product is an antibody conjugated with PE-Cy5 that was generated by immunizing mice against a human adherent peripheral blood cells. It is used only in in vitro assays.
Introduction:
CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily
glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins
on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in
extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains,
and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by activated T
cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium, and some
tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular
antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane
by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and
CD107b on the surface of tumor cell lines has been associated with their enhanced
metastatic potential where they may increase adhesion to extracellular matrix and
endothelium.
glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins
on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in
extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains,
and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by activated T
cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium, and some
tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular
antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane
by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and
CD107b on the surface of tumor cell lines has been associated with their enhanced
metastatic potential where they may increase adhesion to extracellular matrix and
endothelium.
Conjugate:
PE-Cy5
Antibody Isotype:
IgG1
Applications:
In Vitro; Flow Cytometry
Host Species:
Mouse
Species Reactivity:
African green Monkey; Human
Immunogen:
Human adherent peripheral blood cells
Format:
Liquid
Buffer:
Supplied in PBS/NaN3 and a stabilizing agent
Storage:
Store at 4⁰C.
Target:
CD107a
Clone:
B4C3
Clonality:
Monoclonal
Alternative Names:
CD107 antigen-like family member A; CD107a; LAMP-1; lysosomal-associated membrane protein 1; Lysosome-associated membrane glycoprotein 1; lysosome-associated membrane protein 1
Entrez Gene ID:
3916
- CD107a Monoclonal Antibody (B4A3), PE-Cy5 (NHP-AB093) Data Sheet: Detailed information. datasheet
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