HSP27 Monoclonal Antibody (DCS-6) (NHP-AB155)

• This product is an antibody that was generated by immunizing mouse against human leukocytes. It is used only in in vitro assays.

Detailed Product Description

• Introduction: In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock or stress proteins. HSPB1 (heat shock protein beta-1 or HSP27) is a small heat shock protein which functions as a molecular chaperone that maintains denatured proteins in a folding-competent state.
• Conjugate: None
• Antibody Isotype: IgG1κ
• Applications: Flow Cytometry; IF; IHC; WB

Technical Specifications

• Host Species: Mouse
• Species Reactivity: Chicken; Chimpanzee; Human; Mouse; Rat; Sheep
• Immunogen: Purified human HSP27 (earlier called 24K) from breast cancer MCF-7 cells

Product Property

• Purification: Protein G affinity chromatography
• Format: Liquid
• Concentration: 0.2 mg/mL
• Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
• Storage: Store at 4⁰C.

Target Information

• Target: HSP27
• Clone: DCS-6
• Clonality: Monoclonal
• Related Disease: Mutations in the gene can result in Charcot-Marie-Tooth disease 2F and Neuronopathy distal hereditary motor 2B.
• Alternative Names: 28 kDa heat shock protein; DKFZp586P1322; epididymis secretory protein Li 102; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; heat shock 27kD protein 1; heat shock 27kDa protein 1; Heat shock protein; Heat shock protein beta-1; HS; HSP; HSP 27; HspB1; Phospho-HSP 27; SRP27; Stress-responsive protein 27
• Entrez Gene ID: 3315
• Function: It plays a role in stress resistance and actin organization. Through its molecular chaperone activity, HSP27 regulates numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins.