Category:
Non-Human Primate (NHP) related Antibody Products
GM-CSF Monoclonal Antibody (Z5R9v) (NHP-AB255)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing mouse against recombinant human protein. It is used only in in vitro assays.
Introduction:
GM-CSF (Granulocyte-Macrophage colony-stimulating factor) is a 14.6kDa hematopoietic growth factor that exists in glycosylated and non-glycosylated biologically active forms, and stimulates the development of granulocytes, macrophages, early megakaryocytes and eosinophil progenitor cells. The active form of the GM-CSF protein is found extracellularly as a homodimer and the GM-CSF gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q-syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. The ability of recombinant GM-CSF to increase hematopoietic cell recovery has become a focus area in the therapeutic treatment of patients following bone marrow transplantation. Recent studies have investigated GM-CSF in inflammatory and autoimmune diseases such as arthritis, arthritis related interstitial lung disease, nephritis, and psoriasis. In the CNS, GM-CSF depletion or neutralization has been studied in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS).
Conjugate:
None
Antibody Isotype:
IgG2aκ
Applications:
Flow Cytometry; IF; IHC; IP; Neut; WB
Host Species:
Rat
Species Reactivity:
Human; Rhesus
Immunogen:
Recombinant human protein
Purification:
Protein G affinity chromatography
Format:
Liquid
Concentration:
0.2 mg/mL
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Storage:
Store at 4⁰C. Avoid freeze-thaw cycles.
Clone:
Z5R9v
Clonality:
Monoclonal
Alternative Names:
colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; GM-CSF; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; Granulocyte-macrophage colony-stimulating factor; M-GM-CSF; MGC131935; MGC138897; MGC151255; MGC151257; Molgramostin; put. GM-CSF
Entrez Gene ID:
1437
- GM-CSF Monoclonal Antibody (Z5R9v) (NHP-AB255) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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