- This product is an antibody that was generated by immunizing rabbit against a peptide located in the C-Terminal domain of Frizzled 7 (Human). It is used only in in vitro assays.
Detailed Product Description
- Introduction: Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
- Conjugate: None
- Applications: ELISA; IHC
Technical Specifications
- Host Species: Rabbit
- Species Reactivity: Bat; Bovine; Dog; Gibbon; Gorilla; Hamster; Human; Monkey; Mouse; Rabbit; Rat
- Immunogen: A peptide located in the C-Terminal domain of Frizzled 7 (Human)
Product Property
- Purification: Immunoaffinity Chromatography
- Format: Liquid
- Concentration: 1 mg/mL
- Buffer: PBS, 0.1% sodium azide.
- Storage: Short term: 4˚C. Long term: Store at -20˚C.
Target Information
- Clonality: Polyclonal
- Alternative Names: Frizzled 7, seven transmembrane spanning receptor; frizzled family receptor 7; frizzled homolog 7; Frizzled, drosophila, homolog of, 7; Frizzled-7; Fz-7; FzE3; hFz7; mFz7; rizzled 7
- Entrez Gene ID: 8324
Downloadable Resources
FAQs
Customer Reviews
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Q 1: What is the significance of the FZD7 polyclonal antibody in cancer research?
A: The polyclonal antibody against FZD7 is of particular interest in research works that will seek to understand and try to cure cancers that include hepatocellular carcinoma (HCC). Again, FZD7 is among the molecules that have been reported to have high overexpression in HCC, prompting the Wnt/β-catenin pathway, which has been reported to be crucial in the proliferation and migration of cancerous cells. The inhibition of this pathway through the blockade of FZD7 could decrease the possibilities of growth and spread of a cancerous tumor.
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Q 2: How is the FZD7 polyclonal antibody used in laboratory research?
A: The FZD7 polyclonal antibody has been utilized in various experimental techniques, including Western Blot (WB), Immunohistochemistry (Paraffin) (IHC (P)), and Immunocytochemistry (ICC/IF). These methods help in identifying the presence and understanding the function of the FZD7 protein in different cell lines and tissues, offering insights into its role in disease processes, particularly in cancer
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High-Quality and Reliable
The Frizzled 7 Polyclonal Antibody (NHP-AB348) is a product that I have applied in some studies dealing with signaling pathway in the development of cancer. Furthermore, in the Western Blot application, the specificity and sensitivity of this antibody highly defined the reliability for our results, mainly in protein detection of FZD7 in the different kinds of cell line. Very detailed application of the product has been greatly beneficial to the optimization of our own experimental conditions. -
Reliable and Efficient
Frizzled 7 Polyclonal Antibody (NHP-AB348) from Creative Biolabs has eased the fight we have given to research into neurodegenerative diseases. Its use in both WB and ELISA applications has offered us consistent performance and reliable, reproducible results, which are quite critical in our research into the molecular bases that underlie the set of conditions mentioned above. This comprehensive information about the product from Creative Biolabs and proactive customer service have made the research one of the smartest, helping us size and scope the way forward in understanding the role of Frizzled 7 protein in disease pathology.
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