Category:
Non-Human Primate (NHP) related Antibody Products
CD107b Monoclonal Antibody (C4B4), FITC (NHP-AB096)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody conjugated with FITC that was generated by immunizing mice against a human adherent peripheral blood cells. It is used only in in vitro assays.
Introduction:
CD107b, also known as lysosomal-associated membrane protein 2 (LAMP-2), is a heavily glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains and is a ligand for E-selectin-mediated cell adhesion. CD107b is expressed in lysosomal/endosomal membranes and on the surface of activated platelets and some tumor cell lines including U937 and KG1a. LAMP-2 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential where they may increase adhesion to extracellular matrix and endothelium.
Conjugate:
None
Antibody Isotype:
IgG1
Applications:
Flow Cytometry; IHC; WB
Host Species:
Mouse
Species Reactivity:
African green Monkey; Human
Immunogen:
Human adherent peripheral blood cells
Format:
Liquid
Buffer:
Supplied in PBS/NaN3
Storage:
Store at 4⁰C.
Target:
CD107b
Clone:
C4B4
Clonality:
Monoclonal
Alternative Names:
CD107 antigen-like family member B; CD107b; Igp96; LAMP-2; LAMP-2 Isoform 2A; LAMP-2 Variant A; LGP-96; lysosomal-associated membrane protein 2; Lysosome-associated membrane glycoprotein 2; RP23-193O17.2
Entrez Gene ID:
3920
- CD107b Monoclonal Antibody (C4B4), FITC (NHP-AB096) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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