CD35 Monoclonal Antibody (UCHT2), PE (NHP-AB129)

• This product is an antibody conjugated with PE that was generated by immunizing mouse against acute monocytic leukemia cells and normal blood monocytes. It is used only in in vitro assays.

Detailed Product Description

• Introduction: CD35 (CR1, Complement Receptor 1) is a cell membrane-bound, monomeric glycoprotein and its primary function is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. CD35 protein mediates cellular binding to particles and immune complexes that have activated complement. The CD35 complex is four different allotypes (C,A,B,D) C is 160 kDa; A is 190 kDa; B is 220 kDa and D is 250 kDa. CD35 is involved in the processing of immune complexes, promoting of binding and phagocytosis of C3b complexes and inhibition of complement activation. CD35 is on neutrophils, eosinophils, monocytes, B-cells, some NK-cells, erythrocytes, myeloid leukemias, follicular dendritic reticulum cells and is negative on basophils.
• Conjugate: PE
• Antibody Isotype: IgG1
• Applications: Flow Cytometry

Technical Specifications

• Host Species: Mouse
• Species Reactivity: Baboon; Chimpanzee; Human
• Immunogen: Acute monocytic leukemia cells and normal blood monocytes

Product Property

• Format: Liquid
• Buffer: Supplied in PBS/NaN3 and a stabilizing agent
• Storage: Store at 4⁰C.

Target Information

• Target: CD35
• Clone: E11
• Clonality: Monoclonal
• Related Disease: Decreases in expression of CD35 protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in the CD35 gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria.
• Alternative Names: C3-binding protein; C3b/C4b receptor; CD35; CD35 antigen; complement component (3b/4b) receptor 1 (Knops blood group); Complement receptor type 1; Knops blood group antigen
• Entrez Gene ID: 1378