Category:
Non-Human Primate (NHP) related Antibody Products
CD35 Monoclonal Antibody (UCHT2), PE (NHP-AB129)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody conjugated with PE that was generated by immunizing mouse against acute monocytic leukemia cells and normal blood monocytes. It is used only in in vitro assays.
Introduction:
CD35 (CR1, Complement Receptor 1) is a cell membrane-bound, monomeric glycoprotein and its primary function is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. CD35 protein mediates cellular binding to particles and immune complexes that have activated complement. The CD35 complex is four different allotypes (C,A,B,D) C is 160 kDa; A is 190 kDa; B is 220 kDa and D is 250 kDa. CD35 is involved in the processing of immune complexes, promoting of binding and phagocytosis of C3b complexes and inhibition of complement activation. CD35 is on neutrophils, eosinophils, monocytes, B-cells, some NK-cells, erythrocytes, myeloid leukemias, follicular dendritic reticulum cells and is negative on basophils.
Conjugate:
PE
Antibody Isotype:
IgG1
Applications:
Flow Cytometry
Host Species:
Mouse
Species Reactivity:
Baboon; Chimpanzee; Human
Immunogen:
Acute monocytic leukemia cells and normal blood monocytes
Format:
Liquid
Buffer:
Supplied in PBS/NaN3 and a stabilizing agent
Storage:
Store at 4⁰C.
Target:
CD35
Clone:
E11
Clonality:
Monoclonal
Related Disease:
Decreases in expression of CD35 protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in the CD35 gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria.
Alternative Names:
C3-binding protein; C3b/C4b receptor; CD35; CD35 antigen; complement component (3b/4b) receptor 1 (Knops blood group); Complement receptor type 1; Knops blood group antigen
Entrez Gene ID:
1378
- CD35 Monoclonal Antibody (UCHT2), PE (NHP-AB129) Data Sheet: Detailed information. datasheet
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Your research is unique, and we understand that standard products may not always fit. Our team of experts specializes in custom NHP sample collections. We can design a tailored protocol to meet your specific research requirements, including samples with unique anticoagulant types, customized volumes, or from specific disease models.
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For research use only. Not intended for any clinical use.
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