CD4 Monoclonal Antibody (JE1A) (NHP-AB140)

• This product is an antibody that was generated by immunizing mouse against stimulated human leukocytes. It is used only in in vitro assays.

Detailed Product Description

• Introduction: The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene.
• Conjugate: None
• Antibody Isotype: IgG2aκ
• Applications: Flow Cytometry; Func; IF

Technical Specifications

• Host Species: Mouse
• Species Reactivity: Chimpanzee; Human; Orangutan
• Immunogen: Stimulated human leukocytes
• Cross Reactivity: Does not react with Macaca mulatta (Rhesus Monkey)

Product Property

• Purification: Protein G affinity chromatography
• Format: Liquid
• Concentration: 0.2 mg/mL
• Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
• Storage: Store at 4⁰C.

Target Information

• Target: CD4
• Clone: JE1A
• Clonality: Monoclonal
• Alternative Names: CD4; CD4 antigen p55; cd4a; fCD4; Leu-3; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4)
• Entrez Gene ID: 920