CD51 Monoclonal Antibody (C13R6) (NHP-AB099)

• This product is an antibody that was generated by immunizing mice against cell suspension containing osteoclasts from osteoclastomas. It is used only in in vitro assays.

Detailed Product Description

• Introduction: CD51 represents the integrin alphaV chain that associates with integrin beta3 (CD61) to form the CD51/CD61 vitronectin receptor on endothelial cells, certain activated leukocytes, NK cells, macrophages, neutrophils, and platelets. CD51 is the most promiscuous integrin alpha subunit as it can form heterodimers with the beta1 (CD29), beta3 (CD61), beta5, beta6 and beta8 subunits in various tissues. CD51/CD61 acts as an activation-independent receptor for platelet attachment and spreading on vitronectin and other RGD-containing proteins including matrix components. It also mediates leukocyte-endothelial cell adhesion via interaction with CD31.
• Conjugate: None
• Antibody Isotype: IgG1
• Applications: Flow Cytometry; IHC; WB; IP

Technical Specifications

• Host Species: Mouse
• Species Reactivity: African green Monkey; Bovine; Human; Rabbit
• Immunogen: Cell suspension containing osteoclasts from osteoclastomas

Product Property

• Format: Liquid
• Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
• Storage: Store at 4⁰C.

Target Information

• Target: CD51
• Clone: C13R6
• Clonality: Monoclonal
• Alternative Names: Integrin alphaV, vitronectin receptor, VNR-alpha chain
• Entrez Gene ID: 3685