Category:
Non-Human Primate (NHP) related Antibody Products
pS2 Monoclonal Antibody (NR3G) (NHP-AB164)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing mouse against Amino acids 57-84 (CFDDTVRGVPWCFYPNTIDVPPEEECEF) from the human protein. It is used only in in vitro assays.
Introduction:
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
Conjugate:
None
Antibody Isotype:
IgG1κ
Applications:
Flow Cytometry; IF; IHC
Host Species:
Mouse
Species Reactivity:
Cynomolgus; Human
Immunogen:
Amino acids 57-84 (CFDDTVRGVPWCFYPNTIDVPPEEECEF) from the human protein
Purification:
Protein G affinity chromatography
Format:
Liquid
Concentration:
0.2 mg/mL
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Storage:
Store at 4⁰C. Avoid freeze-thaw cycles.
Target:
pS2
Clone:
NR3G
Clonality:
Monoclonal
Alternative Names:
AD3LP; AD5; Alzheimer disease 4; E5-1; Presenilin-2; Presenilin-2 CTF subunit; Presenilin-2 NTF subunit; PS-2; PSEN 2; STM-2
Entrez Gene ID:
7031
- pS2 Monoclonal Antibody (NR3G) (NHP-AB164) Data Sheet: Detailed information. datasheet
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