pS2 Monoclonal Antibody (NR3G) (NHP-AB164)

• This product is an antibody that was generated by immunizing mouse against Amino acids 57-84 (CFDDTVRGVPWCFYPNTIDVPPEEECEF) from the human protein. It is used only in in vitro assays.

Detailed Product Description

• Introduction: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
• Conjugate: None
• Antibody Isotype: IgG1κ
• Applications: Flow Cytometry; IF; IHC

Technical Specifications

• Host Species: Mouse
• Species Reactivity: Cynomolgus; Human
• Immunogen: Amino acids 57-84 (CFDDTVRGVPWCFYPNTIDVPPEEECEF) from the human protein

Product Property

• Purification: Protein G affinity chromatography
• Format: Liquid
• Concentration: 0.2 mg/mL
• Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
• Storage: Store at 4⁰C. Avoid freez-thaw cycles.

Target Information

• Target: pS2
• Clone: NR3G
• Clonality: Monoclonal
• Alternative Names: AD3LP; AD5; Alzheimer disease 4; E5-1; Presenilin-2; Presenilin-2 CTF subunit; Presenilin-2 NTF subunit; PS-2; PSEN 2; STM-2
• Entrez Gene ID: 7031