Category:
Non-Human Primate (NHP) related Antibody Products
CEA Monoclonal Antibody (SL24J) (NHP-AB198)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing mouse against human recombinant CEA protein. It is used only in in vitro assays.
Introduction:
CEA (Carcino Embryonic Antigen, CD66e) is synthesized during development in the fetal gut, and re-expressed in increased amounts in intestinal carcinomas and several other tumors. CEA is a member of carcinoembryonic antigens, immunoglobulin supergene family and consists of a single N domain (structural homology to the immunoglobulin variable) and six immunoglobulin constant-like A (A1, A2, A3) and B domains (B1, B2, B3). Antibodies to CEA are useful in identifying the origin of various metastatic adenocarcinomas and in distinguishing pulmonary adenocarcinomas (60 to 70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.
Conjugate:
None
Antibody Isotype:
IgG1κ
Applications:
Flow Cytometry; IF; IHC
Host Species:
Mouse
Species Reactivity:
Human; Monkey
Immunogen:
Human recombinant CEA protein
Purification:
Protein G affinity chromatography
Format:
Liquid
Concentration:
0.2 mg/mL
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Storage:
Store at 4⁰C. Avoid freeze-thaw cycles.
Target:
CEA
Clone:
SL24J
Clonality:
Monoclonal
Alternative Names:
Carcinoembryonic antigen; Carcinoembryonic antigen-related cell adhesion molecule 5; CD66e; CEA; Meconium antigen 100; OTTHUMP00000199033; sCD66e; soluble CD66e
Entrez Gene ID:
1048
- CEA Monoclonal Antibody (SL24J) (NHP-AB198) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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