Estrogen Inducible Protein pS2 Monoclonal Antibody (C2BR1) (NHP-AB162)

• This product is an antibody that was generated by immunizing mouse against amino acids CFDDTVRGVPWCFYPNTIDVPPEEECEF (aa57-84) from the human protein. It is used only in in vitro assays.

Detailed Product Description

• Introduction: It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
• Conjugate: None
• Antibody Isotype: IgG1κ
• Applications: Flow Cytometry; IF; IHC-P

Technical Specifications

• Host Species: Mouse
• Species Reactivity: Cynomolgus; Human
• Immunogen: Amino acids CFDDTVRGVPWCFYPNTIDVPPEEECEF (aa57-84) from the human protein

Product Property

• Purification: Protein G affinity chromatography
• Format: Liquid
• Concentration: 0.2 mg/mL
• Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
• Storage: Store at 4⁰C. Avoid freez-thaw cycles.

Target Information

• Target: Estrogen Inducible Protein pS2
• Clone: C2BR1
• Clonality: Monoclonal
• Alternative Names: Trefoil factor 1, Breast cancer estrogen-inducible protein, PNR-2, Polypeptide P1.A, hP1.A, Protein pS2, TFF1, BCEI, PS2
• Entrez Gene ID: 7031