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- This product is an antibody that was generated by immunizing rabbit against recombinant fusion protein containing a sequence corresponding to amino acids 100-321 of human FBL (NP_001427.2). It is used only in in vitro assays.
Detailed Product Description
- Introduction: Nop1p / Fibrillarin was originally identified as a nucleolar protein of bakers yeast, Saccharomyces cerevisiae (accession P15646). The Nop1p protein is essential for yeast viability and is localized in the nucleoli. The human homologue of Nop1p is fibrillarin (accession P22087) a component of the nucleolar small nuclear ribonucleoprotein (snRNP) particle. The human fibrillarin gene is located on chromosome 19 (19q13. 1).
- Conjugate: None
- Antibody Isotype: IgG
- Applications: IF; IHC; IP; WB
Technical Specifications
- Host Species: Rabbit
- Species Reactivity: Human; Monkey; Mouse; Rat
- Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 100-321 of human FBL (NP_001427.2)
Product Property
- Purification: Affinity purification
- Format: Liquid
- Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
- Storage: Store at -20⁰C. Avoid freeze-thaw cycles.
Target Information
- Clonality: Polyclonal
- Alternative Names: 34 kDa nucleolar scleroderma antigen; 34-kD nucleolar scleroderma antigen; Histone-glutamine methyltransferase; Nucleolar protein 1; RNA, U3 small nucleolar interacting protein 1; rRNA 2'-O-methyltransferase fibrillarin
- Entrez Gene ID: 2091
Downloadable Resources
FAQs
Customer Reviews
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Q 1: What are the main applications of the FBL Polyclonal Antibody in research?
A: The FBL Polyclonal Antibody is widely utilized in research applications involving cell biology, epigenetics, and molecular biology. It is particularly useful for studying the role of fibrillarin in the nucleolus, including its involvement in ribosome biogenesis, RNA methylation, and the regulation of gene expression. Common applications include Western Blot (WB), Immunohistochemistry (IHC), and Immunofluorescence (IF).
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Q 2: What is the recommended storage condition for the FBL Polyclonal Antibody to maintain its stability?
A: To ensure stability and activity, the FBL Polyclonal Antibody should be stored at -20°C or lower. For long-term storage, avoid repeated freeze-thaw cycles by aliquoting the antibody. Proper storage conditions are critical to preserve the antibody's integrity and functionality for experimental use.
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Consistent and Reproducible Result
As a researcher working on nucleolar protein interactions, I found the FBL Polyclonal Antibody from Creative Biolabs to be an exceptional tool in our lab. The specificity of this antibody for Fibrillarin has greatly enhanced the accuracy of our immunoprecipitation and Western blot experiments. The results are consistent and reproducible, which is critical for our study. Highly recommend this product for anyone working in related fields! -
Highly Recommended
I have been using the FBL Polyclonal Antibody from Creative Biolabs for my nucleolar research, and the results have been consistently impressive. The antibody provides strong, specific signals in both Western blot and immunofluorescence applications, making it easy to identify and analyze fibrillarin expression. The product arrived promptly and was well-packaged, with clear instructions for use.
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NHP Biologicals from Creative Biolabs are for research, diagnostic, or manufacturing purposes only. They may not be intended for or are not approved for any other use.
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