MARCH4 Polyclonal Antibody (NHP-AB274)

• This product is an antibody that was generated by immunizing rabbit against a portion of amino acids 300-350 of human RNF174. It is used only in in vitro assays.

Detailed Product Description

• Introduction: MARCH4 is a multi-pass membrane protein mainly found in the membrane of Golgi apparatus. It is a complex enzyme with a RING-CH-type zinc finger. It acts as a ubiquitin-protein ligase mainly involved in third step of ubiquitin conjugation. The RINGv-type zinc finger domain is required for E3 ligase activity in which the E3 ubiquitin-protein ligase mediates ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. It is mainly expressed in brain and placenta.
• Conjugate: None
• Applications: IHC; WB

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Chicken; Chimpanzee; Dog; Horse; Human; Mouse; Opossum; Rat; Zebrafish
• Immunogen: A portion of amino acids 300-350 of human RNF174

Product Property

• Purification: Immunoaffinity Chromatography
• Format: Liquid
• Concentration: 0.5 mg/mL
• Buffer: PBS, 0.2% gelatin, 0.05% sodium azide.
• Storage: Short term: 4˚C. Long term: Store at -20˚C. Avoid freeze-thaw cycles.

Target Information

• Clonality: Polyclonal
• Alternative Names: E3 ubiquitin-protein ligase MARCH4; MARCH-IV; membrane associated ring finger 4; membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase; Membrane-associated RING finger protein 4; Membrane-associated RING-CH protein IV; RING finger protein 174; RING-type E3 ubiquitin transferase MARCH4
• Entrez Gene ID: 57574