p21 Monoclonal Antibody (UCHT2) (NHP-AB231)

• This product is an antibody that was generated by immunizing mouse against human recombinant protein. It is used only in in vitro assays.

Detailed Product Description

• Introduction: Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.
• Conjugate: None
• Antibody Isotype: IgG1κ
• Applications: Flow Cytometry; IF; IHC

Technical Specifications

• Host Species: Mouse
• Species Reactivity: Human; Monkey; Mouse; Rat
• Immunogen: Human recombinant protein

Product Property

• Purification: Protein G affinity chromatography
• Format: Liquid
• Concentration: 0.2 mg/mL
• Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
• Storage: Store at 4⁰C. Avoid freez-thaw cycles.

Target Information

• Clone: UCHT2
• Clonality: Monoclonal
• Alternative Names: CDK-interacting protein 1; CDK-interaction protein 1; CDNK1A; Cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A (P21); cyclin-dependent kinase inhibitor 1A (p21, Cip1); cyclin-dependent kinase inhibitor 1A variant 1; cyclin-dependent kinase inhibitor 1A variant 2; DNA synthesis inhibitor; MDA-6; melanoma differentiation associated protein 6; Melanoma differentiation-associated protein; Melanoma differentiation-associated protein 6; OTTHUMP00000016298; p21; p21; p21Cip1/Waf1; wild-type p53-activated fragment 1
• Entrez Gene ID: 1026