p53 (phospho Ser392) Polyclonal Antibody (NHP-AB413)

• This product is an antibody that was generated by immunizing rabbit against a synthetic phosphopeptide corresponding to amino acids residues surrounding the phospho-Ser392 of p53. It is used only in in vitro assays.

Detailed Product Description

• Introduction: The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. It has a well established role in the blocking the proliferative action of damaged cells and acting in essence as an anticancer agent. Phosphorylation of Ser392 in p53 is associated with formation of human tumors. In addition, p53 has also been linked to the effects of aging and oxidative stress and an increase in p53 has been linked to deficits in LTP (Long Term Potentiation) in learning and memory. p53 is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy.
• Conjugate: None
• Applications: WB

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Human; Monkey
• Immunogen: A synthetic phosphopeptide corresponding to amino acids residues surrounding the phospho-Ser392 of p53

Product Property

• Purification: Affinity Purified
• Format: Liquid
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Alternative Names: Antigen NY-CO-13; Cellular tumor antigen p53; Cys 51 Stop; FLJ92943; HGNC11998; mutant tumor protein 53; OTTMUSP00000006194; p53; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; Phosphoprotein p53; transformation-related protein 53; tumor protein 53; tumor protein p53 (Li-Fraumeni syndrome); Tumor suppressor p53; tumor supressor p53; Tumour Protein p53
• Entrez Gene ID: 7157