Category:
Non-Human Primate (NHP) related Antibody Products
PCNA Polyclonal Antibody (NHP-AB414)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing rabbit against an internal region of PCNA (Human). It is used only in in vitro assays.
Introduction
PCNA (polymerase delta auxiliary protein) is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumor tissue (i.e. relevant to prognosis). PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. PCNA is found in the nucleus and is a cofactor of DNA polymerase delta, and acts as a homotrimer and helps increase the processing of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of PCNA have been described on chromosome 4 and on the X chromosome.
Conjugate
None
Applications
ELISA; IHC; WB
Host Species
Rabbit
Species Reactivity
Bovine; Chicken; Dog; Fish; Human; Monkey; Mouse; Rat; Xenopus
Immunogen
An internal region of PCNA (Human)
Format
Liquid
Concentration
1 mg/mL
Buffer
0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide
Storage
Store at 4 or -20⁰C. Avoid freeze-thaw cycles.
Clonality
Polyclonal
Alternative Names
Cyclin; DNA polymerase delta auxiliary protein; HGCN8729; MGC8367; PCNA; Proliferating cell nuclear antigen
Entrez Gene ID
5111
- PCNA Polyclonal Antibody (NHP-AB414) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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