PTGER2 Polyclonal Antibody (NHP-AB435)

• This product is an antibody that was generated by immunizing rabbit against a peptide located in the 2nd cytoplasmic domain of PTGER2 (Human). It is used only in in vitro assays.

Detailed Product Description

• Introduction: Prostaglandins are produced by the metabolism of arachidonic acid. Prostaglandin E2 is one of the five physiologically significant prostanoids known. Its wide spectrum of physiologic and pharmacologic effects in various tissues is mediated through binding to the Prostaglandin E2 receptors (EP1, EP2, EP3 & EP4). These include effects on the immune, endocrine, cardiovascular, renal and reproductive systems as well as smooth muscle. It is also one of the most abundant of the prostanoid family in the brain where it plays an important role in many neural functions, particularly in newborn babies, and as a mediator of inflammation. PGE-2 signals through a family of G-protein coupled receptors known as EP receptors. There are 4 subtypes of EP receptors, known as EP1, EP2, EP3 and EP4. EP2 receptors are 358 amino acid proteins with a short third intracellular loop. EP2 receptors stimulate adenylyl cyclase by their coupling to Gs and do not undergo PGE-2-induced internalization. The EP2 receptors is involved with the contraction and relaxation of smooth muscle tissue. These receptors are mainly localized in lung and placental tissues and in smooth muscle.
• Conjugate: None
• Applications: ELISA; IHC-P

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Gibbon; Gorilla; Human; Monkey
• Immunogen: A peptide located in the 2nd cytoplasmic domain of PTGER2 (Human)

Product Property

• Purification: Immunoaffinity Chromatography
• Format: Liquid
• Concentration: 1 mg/mL
• Buffer: PBS, 0.1% sodium azide
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Alternative Names: EP2 receptor; PGE receptor EP2 subtype; PGE receptor, EP2 subtype; PGE2 receptor EP2 subtype; Pge2-r ep2; prostaglandin E receptor 2 (EP2 subtype); prostaglandin E receptor 2 (subtype EP2), 53kD; prostaglandin E receptor 2 (subtype EP2), 53kDa; prostaglandin E receptor EP2 subtype; prostaglandin E receptor subtype EP2; Prostaglandin E2 receptor EP2 subtype; prostaglandin E2 receptor type 2; Prostanoid EP2 receptor
• Entrez Gene ID: 5732
• Function: EP2 receptors stimulate adenylyl cyclase by their coupling to Gs and do not undergo PGE-2-induced internalization. The EP2 receptors is involved with the contraction and relaxation of smooth muscle tissue.