Category:
Non-Human Primate (NHP) related Antibody Products
PELI1 Polyclonal Antibody (NHP-AB421)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
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This product is an antibody that was generated by immunizing rabbit against KLH-conjugated synthetic peptide corresponding to a portion of human Pellino 1 between amino acids 121-135. It is used only in in vitro assays.
Introduction:
The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-Kappa-B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon; and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.
Conjugate:
None
Antibody Isotype:
IgG
Applications:
IHC; WB
Host Species:
Rabbit
Species Reactivity:
Bat; Bovine; Chicken; Dog; Gibbon; Gorilla; Hamster; Horse; Human; Monkey; Mouse; Pig; Rabbit; Rat; Xenopus; Zebrafish
Immunogen:
KLH-conjugated synthetic peptide corresponding to a portion of human Pellino 1 between amino acids 121-135
Purification:
Antiserum
Format:
Liquid
Buffer:
PBS containing 0.05% BSA and 0.05% sodium azide
Storage:
Short term: 4˚C. Long term: Store at -20˚C.
Clonality:
Polyclonal
Alternative Names:
E3 ubiquitin-protein ligase pellino homolog 1; pellino homolog 1; Pellino-1; Pellino-related intracellular-signaling molecule; pellino1; protein pellino homolog 1; RING-type E3 ubiquitin transferase pellino homolog 1
Entrez Gene ID:
57162
- PELI1 Polyclonal Antibody (NHP-AB421) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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