PELI1 Polyclonal Antibody (NHP-AB421)

• This product is an antibody that was generated by immunizing rabbit against KLH-conjugated synthetic peptide corresponding to a portion of human Pellino 1 between amino acids 121-135. It is used only in in vitro assays.

Detailed Product Description

• Introduction: The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-Kappa-B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon; and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.
• Conjugate: None
• Antibody Isotype: IgG
• Applications: IHC; WB

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Bat; Bovine; Chicken; Dog; Gibbon; Gorilla; Hamster; Horse; Human; Monkey; Mouse; Pig; Rabbit; Rat; Xenopus; Zebrafish
• Immunogen: KLH-conjugated synthetic peptide corresponding to a portion of human Pellino 1 between amino acids 121-135

Product Property

• Purification: Antiserum
• Format: Liquid
• Buffer: PBS containing 0.05% BSA and 0.05% sodium azide
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Alternative Names: E3 ubiquitin-protein ligase pellino homolog 1; pellino homolog 1; Pellino-1; Pellino-related intracellular-signaling molecule; pellino1; protein pellino homolog 1; RING-type E3 ubiquitin transferase pellino homolog 1
• Entrez Gene ID: 57162