Perlecan Monoclonal Antibody (BR1C1) (NHP-AB240)

• This product is an antibody that was generated by immunizing mouse against a murine EHS laminin. It is used only in in vitro assays.

Detailed Product Description

• Introduction: Perlecan is a major heparan-sulfate proteoglycan (HSPG) found within all basement membranes and cell surfaces. Because of its strategic location and ability to store and protect growth factors, perlecan has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
• Conjugate: None
• Antibody Isotype: IgG2aκ
• Applications: Flow Cytometry; IF; IHC-P

Technical Specifications

• Host Species: Rat
• Species Reactivity: Bovine; Fish; Monkey; Mouse; Pig
• Immunogen: A murine EHS laminin

Product Property

• Purification: Protein G affinity chromatography
• Format: Liquid
• Concentration: 0.2 mg/mL
• Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
• Storage: Store at 4⁰C. Avoid freeze-thaw cycles.

Target Information

• Clone: BR1C1
• Clonality: Monoclonal
• Alternative Names: Basement membrane-specific heparan sulfate proteoglycan core protein; Endorepellin; endorepellin (domain V region); HSPG; LG3 peptide; Perlecan; perlecan proteoglycan; PLC; RP11-132G19.2
• Entrez Gene ID: 3339