SETD7 / SET7 Polyclonal Antibody (NHP-AB452)

• This product is an antibody that was generated by immunizing rabbit against two synthetic peptides corresponding to amino acids 131-145 and 336-352 of human Set7/9 were used as immunogen. It is used only in in vitro assays.

Detailed Product Description

• Introduction: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
• Conjugate: None
• Antibody Isotype: IgG
• Applications: IHC; WB

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Bat; Bovine; Dog; Gibbon; Gorilla; Hamster; Horse; Human; Monkey; Mouse; Rabbit; Rat
• Immunogen: Two synthetic peptides corresponding to amino acids 131-145 and 336-352 of human Set7/9 were used as immunogen

Product Property

• Purification: Antiserum
• Format: Liquid
• Buffer: PBS, 0.2% gelatin, 0.05% sodium azide
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Alternative Names: FLJ21193; H3-K4 methyltransferase; H3-K4-HMTase SETD7; Histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; Histone-lysine N-methyltransferase SETD7; Lysine N-methyltransferase 7; OTTHUMP00000220049; SET domain containing (lysine methyltransferase) 7; SET domain containing 7, lysine methyltransferase; SET domain containing lysine methyltransferase 7; SET domain-containing protein 7; SET7/9
• Entrez Gene ID: 80854