Category:
Non-Human Primate (NHP) related Antibody Products
SETD7 / SET7 Polyclonal Antibody (NHP-AB452)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
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This product is an antibody that was generated by immunizing rabbit against two synthetic peptides corresponding to amino acids 131-145 and 336-352 of human Set7/9 were used as immunogen. It is used only in in vitro assays.
Introduction:
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Conjugate:
None
Antibody Isotype:
IgG
Applications:
IHC; WB
Host Species:
Rabbit
Species Reactivity:
Bat; Bovine; Dog; Gibbon; Gorilla; Hamster; Horse; Human; Monkey; Mouse; Rabbit; Rat
Immunogen:
Two synthetic peptides corresponding to amino acids 131-145 and 336-352 of human Set7/9 were used as immunogen
Purification:
Antiserum
Format:
Liquid
Buffer:
PBS, 0.2% gelatin, 0.05% sodium azide
Storage:
Short term: 4˚C. Long term: Store at -20˚C.
Clonality:
Polyclonal
Alternative Names:
FLJ21193; H3-K4 methyltransferase; H3-K4-HMTase SETD7; Histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; Histone-lysine N-methyltransferase SETD7; Lysine N-methyltransferase 7; OTTHUMP00000220049; SET domain containing (lysine methyltransferase) 7; SET domain containing 7, lysine methyltransferase; SET domain containing lysine methyltransferase 7; SET domain-containing protein 7; SET7/9
Entrez Gene ID:
80854
- SETD7 / SET7 Polyclonal Antibody (NHP-AB452) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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