PTGER3 Polyclonal Antibody (NHP-AB436)

• This product is an antibody that was generated by immunizing rabbit against a peptide located in the 3rd cytoplasmic domain of PTGER3 (Human). It is used only in in vitro assays.

Detailed Product Description

• Introduction: PTGER3, also known as signal-regulatory protein alpha, is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and haematopoietic stem cells. PTGER3 acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways. Ligand binding of PTGER3 to integrin-associated protein CD47, results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of PTGER3, mediating the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2. These then act as regulators of cellular function, through dephosphorylation of specific substrates. Ligation of PTGER3 with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs.
• Conjugate: None
• Applications: ELISA; IHC

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Bat; Gibbon; Gorilla; Horse; Human; Monkey; Mouse; Rabbit; Rat
• Immunogen: A peptide located in the 3rd cytoplasmic domain of PTGER3 (Human)

Product Property

• Purification: Immunoaffinity Chromatography
• Format: Liquid
• Concentration: 1 mg/mL
• Buffer: PBS, 0.1% sodium azide
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Alternative Names: Ep3 receptor; MGC141828; MGC141829; MGC27302; PGE receptor EP3 subtype; PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; PGE2-R; pr; prostaglandin E receotor EP3 subtype 3 isoform; prostaglandin E receptor 3 (subtype EP3); Prostaglandin E2 receptor EP3 subtype; prostaglandin receptor (PGE-2); Prostanoid EP3 receptor
• Entrez Gene ID: 5733