STAT3 Polyclonal Antibody (KO Validated) (NHP-AB467)

• This product is an antibody that was generated by immunizing rabbit against recombinant fusion protein containing a sequence corresponding to amino acids 640-770 of human STAT3 (NP_644805.1). It is used only in in vitro assays.

Detailed Product Description

• Introduction: STAT3 belongs to the family of STAT (signal transducers and activators of transcription) proteins which are phosphorylated by receptor associated kinases, translocate to the nucleus, and act as transcription factors in response to cytokines and growth factors. Coactivators such as CREB-binding protein are required for the transcriptional activation by STAT3. STAT3 can also be activated by Interferon-alpha, Interferon-gamma, EGF, PDGF and IL6. Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for STAT3 dimer formation, nuclear translocation, and DNA binding activity.
• Conjugate: None
• Antibody Isotype: IgG
• Applications: IF; IHC; WB

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Human; Monkey; Mouse; Rat
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 640-770 of human STAT3 (NP_644805.1)

Product Property

• Purification: Affinity purification
• Format: Liquid
• Concentration: 0.5 mg/mL
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Storage: Store at -20⁰C. Avoid freez-thaw cycles.

Target Information

• Clonality: Polyclonal
• Alternative Names: Acute phase response factor; Acute-phase response factor; DNA-binding protein APRF; FLJ20882; MGC16063; Signal transducer and activator of transcription 3; signal transducer and activator of transcription 3 (acute-phase response factor); STAT
• Entrez Gene ID: 6774