Cynomolgus Monkey PBMCs- Rhesus Monkey PBMCs
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- This product is an antibody that was generated by immunizing mouse against recombinant human protein. It is used only in in vitro assays.
Detailed Product Description
- Introduction: TLR2 is a member of the Toll-like receptor (TLR) family which play a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. TLR2 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Ten human homologs of TLRs (TLR1-10) have been described.
- Conjugate: None
- Antibody Isotype: IgG2aκ
- Applications: Flow Cytometry; Func; IF; IHC-P; WB
Technical Specifications
- Host Species: Mouse
- Species Reactivity: Dog; Human; Monkey
- Immunogen: Recombinant human protein
Product Property
- Purification: Protein G affinity chromatography
- Format: Liquid
- Concentration: 0.2 mg/mL
- Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
- Storage: Store at 4⁰C. Avoid freeze-thaw cycles.
Target Information
- Clone: U33.R4
- Clonality: Monoclonal
- Alternative Names: CD282; TLR-2; Toll-like receptor 2; toll-like receptor 2 variant 1; toll-like receptor 2 variant 2; Toll/interleukin-1 receptor-like protein 4
- Entrez Gene ID: 7097
Downloadable Resources
FAQs
Customer Reviews
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Q 1: How can the TLR2 Monoclonal Antibody (U33.R4) improve the specificity of immune response detection in my research?
A: The TLR2 Monoclonal Antibody (U33.R4) is designed to bind specifically to the Toll-like Receptor 2 (TLR2), a critical component in the innate immune system's response to microbial pathogens. By targeting TLR2, this antibody allows me to accurately identify and quantify TLR2-mediated immune responses, leading to more precise understanding of pathogen recognition and immune activation mechanisms. This specificity is crucial for studies involving microbial infection, inflammation, and immune regulation.
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Q 2: In which applications is the TLR2 Monoclonal Antibody (U33.R4) most effectively used?
A: The TLR2 Monoclonal Antibody (U33.R4) is versatile and can be applied in various research settings, including flow cytometry, Western blotting, immunohistochemistry, and ELISA. It's particularly useful in studying the role of TLR2 in bacterial, fungal, and viral infections, as well as in autoimmune diseases and inflammatory conditions. This antibody's ability to specifically detect TLR2 expression in different cell types makes it an invaluable tool for detailed immunological research and therapeutic target exploration.
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High Specificity & Consistent Performance
Utilizing the TLR2 Monoclonal Antibody (U33.R4) in our lab has significantly advanced our research in innate immunity. Its high specificity and consistent performance in detecting TLR2 have enabled us to uncover nuanced insights into pathogen recognition processes. This antibody is a reliable tool for our immunological assays. -
Highly Recommended
As a researcher focusing on inflammatory diseases, finding the TLR2 Monoclonal Antibody (U33.R4) was a breakthrough. Its effectiveness in both Western blotting and immunohistochemistry has been unparalleled, providing clear and reproducible results. I highly recommend this product for anyone studying TLR2's role in immune responses.
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NHP Biologicals from Creative Biolabs are for research, diagnostic, or manufacturing purposes only. They may not be intended for or are not approved for any other use.
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