ABCB1 Polyclonal Antibody (NHP-AB289)

• This product is an antibody that was generated by immunizing rabbit against amino acids 262 - 277 of ABCB1 (Human). It is used only in in vitro assays.

Detailed Product Description

• Introduction: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
• Conjugate: None
• Applications: ELISA; IHC; WB

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Dog; Human; Monkey; Mouse; Rat
• Immunogen: Amino acids 262 - 277 of ABCB1 (Human)

Product Property

• Purification: Immunoaffinity Chromatography
• Format: Liquid
• Concentration: 1 mg/mL
• Buffer: 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Alternative Names: ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-dependent translocase ABCB1; CD243; colchicin sensitivity; doxorubicin resistance; Multidrug resistance protein 1; P-glycoprotein 1; Phospholipid transporter ABCB1
• Entrez Gene ID: 5243