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- This product is an antibody that was generated by immunizing rabbit against synthetic 18 amino acid peptide from internal region of human TMEM33. It is used only in in vitro assays.
Detailed Product Description
- Introduction: Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling.
- Conjugate: None
- Applications: IHC
Technical Specifications
- Host Species: Rabbit
- Species Reactivity: Bat; Bovine; Dog; Gibbon; Gorilla; Horse; Human; Monkey; Pig
- Immunogen: Synthetic 18 amino acid peptide from internal region of human TMEM33
Product Property
- Purification: Immunoaffinity Chromatography
- Format: Liquid
- Concentration: 0.8 mg/mL
- Buffer: PBS, 0.1% sodium azide
- Storage: Short term: 4˚C. Long term: Store at -20˚C.
Target Information
- Clonality: Polyclonal
- Alternative Names: Protein DB83; SHINC-3; Transmembrane protein 33
- Entrez Gene ID: 55161
Downloadable Resources
FAQs
Customer Reviews
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Q 1: What are the main concerns regarding TMEM33 polyclonal antibody research?
A: In consideration of the aforesaid attributes, the current researchers will examine the specificity and any possible cross-reactivity of TMEM33 polyclonal antibody. Given that TMEM33 is reported to act as a modulator for the shape and dynamics of the endoplasmic reticulum (ER) network and is identified to participate in the signaling pathway of the unfolded protein response, the importance of detecting it accurately cannot be overstated in relation to its physiological functions. This possibility can be achieved only through the biological activity of this protein when the antibodies hold specificity in determining the binding target and do not show any reactivity against any non-targeted proteins.
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Q 2: How do TMEM33 polyclonal antibodies contribute to understanding TMEM33's function in cellular processes?
A: The polyclonal antibodies of antibody TMEM33 can be used for the determination in the regulation of the structure of the tubular endoplasmic reticulum network, consistent with the functionality of the unfolded protein response signaling. TMEM33 senses both the static and the dynamic part of the ER. The antibody allows the detection of its localization in the diversity of cell types and tissues, which points to its importance in the preservation of cellular homeostasis and in the response to ER stress.
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Well Performance
The antibody's performance in Western Blot is very well. It undoubtedly accelerated the progress of my experiments.
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NHP Biologicals from Creative Biolabs are for research, diagnostic, or manufacturing purposes only. They may not be intended for or are not approved for any other use.
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