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De Novo Human/Humanized Antibody Sequencing Service

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The generation of human or humanized antibodies to human antigens is of particular interest for the treatment of a variety of diseases. Creative Biolabs is pleased to present world-leading de novo Human/Humanized Antibody Sequencing service. Scientists from Creative Biolabs has developed de novo antibody sequencing technology: Database Assisted Shotgun Sequencing (DASS), which is an analytical method that derives an antibody’s amino acid sequence from its tandem mass spectrum (MS/MS) without the assistance of a sequence database. It is in contrast to another popular peptide identification approach: “database search”, which searches in a given database to find the target peptide.

<em>De Novo</em> Human/Humanized Antibody Sequencing Service

Humanized antibodies are antibodies from non-human species whose protein sequences have been modified to increase their similarity to antibody variants produced naturally in humans. Humanization can be necessary when the process of developing a specific antibody involves generation in a non-human immune system. Humanized antibodies are distinct from chimeric antibodies. Although the creation of an antibody chimera is normally undertaken to achieve a more human-like antibody, simple chimeras of this type are not usually referred to as humanized. Rather, the protein sequence of a humanized antibody is essentially identical to that of a human variant, despite the CDRs responsible for the ability of the antibody to bind to its target antigen.

A clear advantage of de novo sequencing from Creative Biolabs is that it works for both database and novel peptides. This is critically important for samples such as antibodies, since antibodies harbor variable regions. We provide human/humanized antibody sequencing services with full length coverage and 100% accuracy to satisfy our customer's requirements.

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