Aeroplysinin 1 (ADC-P-054)

ADCs Toxins, The sponge Aplysina aerophoba Schmidt belogns to the family Aplysinidae, which may can be found in tropical and subtroical parts. Aeroplysinin-1, a brominated antibiotic, has a wide spectrum of anti-tumoral action and behaves as a potent anti-angiogenic compound for bovine aortic endotheliseems to have cytotoxic activites against HeLa tumor cells. An experimental approach confirmed effects on MCP-1 and TSP-1. Aeroplysinin reduced the viability of AML cells in a dose depentent manner with IC50 of 10-20 µm.