Anti-IL12+IL23 (Ustekinumab)-MC-Vc-PAB-MMAE ADC (ADC-W-1955)

 ADC Target

  • Name
  • IL12+IL23
  • Alternative Names
  • IL12+IL23
  • Overview
  • Interleukin-12 (IL-12; one of the most important T helper 1 (Th1) cytokines) is a component of the complex signal network between lymphoid and neoplastic cells. Systemic or local administration of IL-12 upregulates vascular endothelial adhesion molecule-1 on the endothelial surface, recruits leukocytes to the tumor site, and leads to ischemic–hemorrhagic necrosis of the tumor. IL-12 also inhibits tumor angiogenesis. Interleukin-23 (IL-23) is a heterodimeric cytokine composed of an IL12B (IL-12p40) subunit (that is shared with IL12) and the IL23A (IL-23p19) subunit. A functional receptor for IL-23 (the IL-23 receptor) has been identified and is composed of IL-12R β1 and IL-23R.

 ADC Antibody

  • Overview
  • Human Anti-IL12+IL23 IgG1-kappa antibody, Ustekinumab
  • Generic name
  • Ustekinumab
  • Host animal
  • Human

 ADC Linker

  • Name
  • MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

 ADC payload drug

  • Name
  • MMAE
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Related Products

Online Inquiry
*E-mail Address:
*Products or Services Interested:
Project Description:
*Verification Code:
Please input "biolabs"(case insensitive) as verification code.

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

Contact us
 45-1 Ramsey Road, Shirley, NY 11967, USA
 Tel: 1-631-357-2254
 Fax: 1-631-207-8356
Heidenkampsweg 58, 20097 Hamburg, Germany
 Tel: 44-207-097-1828