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In the stringent arena of pharmaceutical quality control, the LAL endotoxin testing is unmatched in its sensitivity. The LAL assay relies on a cascaded network of divalent cation-dependent enzymes, it is highly susceptible to chemical interference. Samples containing chelating agents (e.g., EDTA, citrate, phosphates) strip the testing environment of essential ions, rendering the reagent inert and causing dangerous false-negative results. Creative Biolabs' Pyrogen-Free Magnesium (MgCl₂) Buffer is a specialized solution designed to counteract this chelation effect. By replenishing essential magnesium ions in a single, simple dilution step, this formulation restores the required enzymatic cofactors without introducing exogenous endotoxin. It provides quality control laboratories with a validated tool to neutralize sample interference, protect assay linearity and secure reliable batch release data.