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Lot Number
Pyrogen-free 50 mM Tris Buffer (ES-0526-YC224)
Catalog: ES-0526-YC224
Product Type: Pyrogen-Free Buffer
Sub Cat
Endotoxin Level
Size
Product Overview
Product Overview
In pharmaceutical quality control and medical device validation, the Limulus Amebocyte Lysate (LAL) assay stands as the gold standard for bacterial endotoxin detection. However, the LAL cascade is a highly sensitive, multi-enzyme system driven by delicate serine proteases. A critical factor frequently overlooked during testing is sample pH. If a test analyte or matrix shifts the assay environment outside the narrow physiological sweet spot, the LAL enzymes are inhibited, leading to false-negative results or severely suppressed recovery rates. Creative Biolabs' Pyrogen-Free 50 mM Tris Buffer is an ultra-pure and endotoxin-free buffering solution engineered specifically to overcome sample-induced pH inhibition. By replacing or supplementing general dilution water with this specialized formulation, you can seamlessly stabilize your testing matrix within the optimal phosophodiester and protease activation range of pH 6.0 to 8.0. It offers a one-step solution to neutralize highly acidic, basic, or weakly buffered formulations, safeguarding your lab from regulatory non-compliance and missed contamination.
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