Category:
Non-Human Primate (NHP) related Antibody Products
BACE1 Polyclonal Antibody (NHP-AB309)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing rabbit against a peptide located near the internal domain of BACE1 (Human). It is used only in in vitro assays.
Introduction:
Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis Alzheimer's disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor(APP) at b- and g-sites by two proteases. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all sufferers of Alzheimer's disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). bACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
Conjugate:
None
Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Bat; Bovine; Dog; Gibbon; Guinea Pig; Hamster; Horse; Human; Monkey; Mouse; Pig; Rabbit; Rat
Immunogen:
A peptide located near the internal domain of BACE1 (Human)
Purification:
Immunoaffinity Chromatography
Format:
Liquid
Concentration:
1 mg/mL
Buffer:
PBS, 0.1% sodium azide
Storage:
Short term: 4˚C. Long term: Store at -20˚C.
Clonality:
Polyclonal
Alternative Names:
APP beta-secretase; asp 2; ASP2; Aspartyl protease 2; BACE 1; BACE-1D; BACE-I-432; Beta secretase; Beta-secretase 1; beta-secretase 1 precursor variant 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme 1; Memapsin; Memapsin-2; Memapsin2; Membrane-associated aspartic protease 2; transmembrane aspartic proteinase Asp2
Entrez Gene ID:
23621
- BACE1 Polyclonal Antibody (NHP-AB309) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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