BimS/EL/L Monoclonal Antibody (WA-1) (NHP-AB175)

• This product is an antibody that was generated by immunizing rat against synthetic peptide corresponding to aa 20-40 of mouse BimL. It is used only in in vitro assays.

Detailed Product Description

• Introduction: BIM belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
• Conjugate: None
• Antibody Isotype: IgG2a
• Applications: ELISA; Flow Cytometry; ICC; IHC; IP; WB

Technical Specifications

• Host Species: Rat
• Species Reactivity: Dog; Human; Monkey; Mouse; Rat
• Immunogen: Synthetic peptide corresponding to aa 20-40 of mouse BimL.

Product Property

• Purification: SDS-PAGE
• Format: Liquid
• Concentration: 1 mg/mL
• Buffer: In PBS containing 0.02% sodium azide and 25% glycerol.
• Storage: Stable for at least 1 year after receipt when stored at -20˚C.

Target Information

• Target: BimS/EL/L
• Clone: WA-1
• Clonality: Monoclonal
• Alternative Names: bcl-2 interacting mediator of cell death; bcl-2 interacting protein Bim; Bcl-2 like 11; Bcl-2 related apoptotic gene product BimL; Bcl-2-like protein 11; bcl-2-related ovarian death agonist; Bcl-2-related ovarian death protein; Bcl2 interacting mediator of cell death; Bcl2-interacting mediator of cell death; Bcl2-L-11; BCL2-like 11 (apoptosis facilitator); Bim EL; Bim-A; BIM-alpha6; BIM-beta6; BIM-beta7; OTTHUMP00000197013; OTTHUMP00000204247