What is the role of Caspase 7 Monoclonal Antibody in apoptosis research?

It is crucial for identifying and quantifying Caspase 7's involvement in the apoptosis pathway, providing insights into cell death mechanisms critical for understanding disease processes and potential therapeutic targets.

Can Caspase 7 Monoclonal Antibody be used in cancer research?

Yes, due to Caspase 7's role in programmed cell death, this antibody is invaluable for studying cancer cells' resistance to apoptosis, offering potential pathways for therapeutic intervention.

Category: Non-Human Primate (NHP) related Antibody Products

Caspase 7 Monoclonal Antibody (R4LA) (NHP-AB178)

Product Overview Detailed Product Description Technical Specifications Product Property Target Information Downloadable Resources FAQs Customer Reviews

This product is an antibody that was generated by immunizing mouse against recombinant human CASP7. It is used only in in vitro assays.

Introduction: Caspase 7 is part of a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase 7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression. Alternative splicing results in four transcript variants, encoding three distinct isoforms of Caspase 7.

Conjugate: None

Antibody Isotype: IgG

Applications: IHC; WB

Host Species: Mouse

Species Reactivity: Dog; Hamster; Human; Monkey; Mouse; Pig; Rabbit; Rat; Sheep

Immunogen: Recombinant human CASP7

Purification: Protein G Column

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS (10 mM sodium phosphate, pH 7.2, 50 mM sodium chloride, 0.1 mM PMSF)

Storage: Short term: 4˚C. Long term: Store at -20˚C. Avoid freeze-thaw cycles.

Target: Caspase 7

Clone: R4LA

Clonality: Monoclonal

Related Disease: Diseases associated with CASP7 include Type 1 Diabetes Mellitus 17 and Aleutian Mink Disease.

Alternative Names: Apoptotic protease Mch-3; CASP-7; caspase 7, apoptosis-related cysteine peptidase; caspase 7, apoptosis-related cysteine protease; Caspase-7; Caspase-7 subunit p11; Caspase-7 subunit p20; CMH-1; ICE-LAP3; ICE-like apoptotic protease 3; OTTHUMP00000020511; OTTHUMP00000020513; OTTHUMP00000020514; RP11-211N11.6

Entrez Gene ID: 840

Caspase 7 Monoclonal Antibody (R4LA) (NHP-AB178) Data Sheet: Detailed information. datasheet

Q 1: What is the role of Caspase 7 Monoclonal Antibody in apoptosis research?
A: It is crucial for identifying and quantifying Caspase 7's involvement in the apoptosis pathway, providing insights into cell death mechanisms critical for understanding disease processes and potential therapeutic targets.
Q 2: Can Caspase 7 Monoclonal Antibody be used in cancer research?
A: Yes, due to Caspase 7's role in programmed cell death, this antibody is invaluable for studying cancer cells' resistance to apoptosis, offering potential pathways for therapeutic intervention.

Unmatched Specificity,
Implementing the Caspase 7 Monoclonal Antibody (R4LA) into our apoptosis research protocols has significantly enhanced the precision of our experiments. The antibody's specificity is unmatched, providing clear, consistent results.
Amazing Effectiveness
The R4LA Caspase 7 Monoclonal Antibody has been a game-changer for our cancer studies. Its effectiveness in identifying apoptotic pathways has opened up new avenues for targeted therapy research.

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Fig.1 Obesity can be counteracted by gene regulation.

Your research is unique, and we understand that standard products may not always fit. Our team of experts specializes in custom NHP sample collections. We can design a tailored protocol to meet your specific research requirements, including samples with unique anticoagulant types, customized volumes, or from specific disease models.