What makes ERBB2 (HER2) Polyclonal Antibody essential for cancer research?

ERBB2 (HER2) Polyclonal Antibody is crucial for cancer research, particularly in studying breast and gastric cancers where HER2 plays a significant role in tumor progression. It helps in detecting HER2 overexpression, facilitating the understanding of cancer biology and the development of targeted therapies.

Can ERBB2 (HER2) Polyclonal Antibody be used in diagnostic applications?

While primarily used for research purposes, ERBB2 (HER2) Polyclonal Antibody has potential in diagnostic applications, especially in identifying HER2-positive cancers. Its accuracy and specificity make it a valuable tool in developing diagnostic assays and personalized treatment plans.

Category: Non-Human Primate (NHP) related Antibody Products

ERBB2 (HER2) Polyclonal Antibody (NHP-AB340)

Product Overview Detailed Product Description Technical Specifications Product Property Target Information Downloadable Resources FAQs Customer Reviews

This product is an antibody that was generated by immunizing rabbit against synthetic 13 amino acid peptide from N-Terminal extracellular domain of human ERBB2 / HER2. It is used only in in vitro assays.

Introduction: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Conjugate: None

Applications: IHC

Host Species: Rabbit

Species Reactivity: Bovine; Dog; Gibbon; Gorilla; Horse; Human; Monkey

Immunogen: Synthetic 13 amino acid peptide from N-Terminal extracellular domain of human ERBB2 / HER2

Purification: Immunoaffinity Chromatography

Format: Liquid

Concentration: 0.6 mg/mL

Buffer: PBS, 0.1% sodium azide.

Storage: Short term: 4˚C. Long term: Store at -20˚C.

Clonality: Polyclonal

Alternative Names: avian erythroblastosis oncogene B 2; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); c-erb B2/neu protein; C-erbB-2; CD antigen CD340; CD340; epidermal growth factor receptor-related protein; erb-b2; erbb 2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; herstatin; human epidermal growth factor receptor 2; metas; Metastatic lymph node gene 19 protein; MLN 19; Neu oncogene; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; p185erbB2; p185neu; phospho ErbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

Entrez Gene ID: 2064

ERBB2 (HER2) Polyclonal Antibody (NHP-AB340) Data Sheet: Detailed information. datasheet

Q 1: What makes ERBB2 (HER2) Polyclonal Antibody essential for cancer research?
A: ERBB2 (HER2) Polyclonal Antibody is crucial for cancer research, particularly in studying breast and gastric cancers where HER2 plays a significant role in tumor progression. It helps in detecting HER2 overexpression, facilitating the understanding of cancer biology and the development of targeted therapies.
Q 2: Can ERBB2 (HER2) Polyclonal Antibody be used in diagnostic applications?
A: While primarily used for research purposes, ERBB2 (HER2) Polyclonal Antibody has potential in diagnostic applications, especially in identifying HER2-positive cancers. Its accuracy and specificity make it a valuable tool in developing diagnostic assays and personalized treatment plans.

High Specificity & High Sensitivity
Using the ERBB2 (HER2) Polyclonal Antibody from Creative Biolabs has significantly advanced our lab's breast cancer research. Its specificity and sensitivity in detecting HER2 expression have been pivotal for our studies, contributing to a deeper understanding of tumor biology and potential therapeutic targets.
Good Quality
The quality and reliability of the ERBB2 (HER2) Polyclonal Antibody provided by Creative Biolabs have made a notable difference in our oncological research projects. It's been instrumental in our work on personalized medicine, allowing us to accurately identify HER2-positive cases and explore novel treatment avenues.

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Fig.1 Obesity can be counteracted by gene regulation.

Your research is unique, and we understand that standard products may not always fit. Our team of experts specializes in custom NHP sample collections. We can design a tailored protocol to meet your specific research requirements, including samples with unique anticoagulant types, customized volumes, or from specific disease models.