CD95 Monoclonal Antibody (CM5R.1), PE (NHP-AB106)

• This product is an antibody conjugated with PE that was generated by immunizing mice against human CD95 transfected L cells. It is used only in in vitro assays.

Detailed Product Description

• Introduction: CD95, also known as Fas and APO-1, is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC) and activation of caspases. The auto-proteolytic processing of the caspases in the complex trigger a downstream cascade that leads to apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. The Fas/Fas ligand system has been shown to play a role in a number of human diseases such as AIDS, hepatitis and cancer. It is also assumed that induction of apoptosis through FAS ligand pathway is predominantly involved in anti-viral immune responses.
• Conjugate: PE
• Antibody Isotype: IgG1
• Applications: Flow Cytometry

Technical Specifications

• Host Species: Mouse
• Species Reactivity: African green Monkey; Human
• Immunogen: Human CD95 transfected L cells

Product Property

• Format: Liquid
• Buffer: Supplied in PBS/NaN3 and a stabilizing agent
• Storage: Store at 4⁰C.

Target Information

• Target: CD95
• Clone: CM5R.1
• Clonality: Monoclonal
• Alternative Names: Apo-1 antigen; APO-1 cell surface antigen; Apo-1 Fas; Apo1 antigen; apoptosis antigen 1; apoptosis signaling receptor FAS; Apoptosis-mediating surface antigen FAS; CD95; CD95 antigen; Fas (TNF receptor superfamily, member 6); Fas AMA; FASLG receptor; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; TNF receptor superfamily member 6; Tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6
• Entrez Gene ID: 355