Category:
Non-Human Primate (NHP) related Antibody Products
CTCF Polyclonal Antibody (NHP-AB326)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing rabbit against recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human CTCF (NP_006556.1). It is used only in in vitro assays.
Introduction
Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain containing, DNA-binding nuclear phosphoprotein that is involved in multiple aspects of normal gene regulation including transcriptional repression and activation, gene silencing, chromatin insulation and regulation of imprinted sites. CTCF uses different combinations of ZF domains and interacts with the CCCTC motif on the DNA. It can bind to HAT- and HDAC-containing complexes thereby influencing transcriptional activation or repression respectively. It is a multifunctional protein involved in the transactivation of APPB gene, silencing of c-myc gene, and insulation of human beta-globin and DMI myotonic dystrophy locus and imprinting control of IGF2 and H19 regions. CTCF has also been shown to regulate the transcription of Pax6 and IRAK2 promoter thereby opening a therapeutic avenue. Mutations in this gene have been associated with invasive breast cancers, prostate cancers and Wilms' tumors.
Conjugate
None
Antibody Isotype
IgG
Applications
ChIP; IF; IHC; IP; WB
Host Species
Rabbit
Species Reactivity
Human; Monkey; Mouse; Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human CTCF (NP_006556.1)
Purification
Affinity purification
Format
Liquid
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage
Store at -20⁰C. Avoid freeze-thaw cycles.
Clonality
Polyclonal
Related Disease
Mutations in this gene have been associated with invasive breast cancers, prostate cancers and Wilms' tumors.
Alternative Names
11 zinc finger transcriptional repressor; 11-zinc finger protein; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein); CTCFL paralog; OTTHUMP00000197610; Transcriptional repressor CTCF
Entrez Gene ID
10664
- CTCF Polyclonal Antibody (NHP-AB326) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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