IFN-gamma Monoclonal Antibody (V23K9) (NHP-AB156)

• This product is an antibody that was generated by immunizing mouse against E. coli-expressed human IFN-gamma. It is used only in in vitro assays.

Detailed Product Description

• Introduction: IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway.
• Conjugate: None
• Antibody Isotype: IgG1
• Applications: ELISA; Flow Cytometry; ICC; IHC-Fr; IHC-P; IP; WB

Technical Specifications

• Host Species: Mouse
• Species Reactivity: African green Monkey; Chimpanzee; Human
• Immunogen: E. coli-expressed human IFN-gamma

Product Property

• Format: Liquid
• Concentration: 0.5 mg/mL
• Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
• Storage: Store at 4⁰C.

Target Information

• Target: IFN-gamma
• Clone: V23K9
• Clonality: Monoclonal
• Related Disease: IFN gamma gene mutations are associated with aplastic anemia.
• Alternative Names: gamma interferon; H-IFN-g; IFN γ; IFN-gamma; IFN-y; IFNγ; Interferon gamma; Interferon y; Interferon γ; Interferonγ; M-IFN-g; R-IFN-g
• Entrez Gene ID: 3458