Category:
Non-Human Primate (NHP) related Antibody Products
IFN-gamma Monoclonal Antibody (V23K9) (NHP-AB156)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing mouse against E. coli-expressed human IFN-gamma. It is used only in in vitro assays.
Introduction:
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway.
Conjugate:
None
Antibody Isotype:
IgG1
Applications:
ELISA; Flow Cytometry; ICC; IHC-Fr; IHC-P; IP; WB
Host Species:
Mouse
Species Reactivity:
African green Monkey; Chimpanzee; Human
Immunogen:
E. coli-expressed human IFN-gamma
Format:
Liquid
Concentration:
0.5 mg/mL
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Storage:
Store at 4⁰C.
Target:
IFN-gamma
Clone:
V23K9
Clonality:
Monoclonal
Related Disease:
IFN gamma gene mutations are associated with aplastic anemia.
Alternative Names:
gamma interferon; H-IFN-g; IFN γ; IFN-gamma; IFN-y; IFNγ; Interferon gamma; Interferon y; Interferon γ; Interferonγ; M-IFN-g; R-IFN-g
Entrez Gene ID:
3458
- IFN-gamma Monoclonal Antibody (V23K9) (NHP-AB156) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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