Integrin alpha 4 Polyclonal Antibody (NHP-AB390)

• This product is an antibody that was generated by immunizing rabbit against a peptide located in the C-Terminal domain of Integrin alpha 4 (Human). It is used only in in vitro assays.

Detailed Product Description

• Introduction: The integrin alpha 4, also known as CD49d and ITGA4, belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
• Conjugate: None
• Applications: IHC

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Bat; Dog; Gibbon; Gorilla; Hamster; Human; Monkey; Mouse; Pig; Rabbit; Rat
• Immunogen: A peptide located in the C-Terminal domain of Integrin alpha 4 (Human)

Product Property

• Purification: Immunoaffinity Chromatography
• Format: Liquid
• Concentration: 1 mg/mL
• Buffer: PBS, 0.1% sodium azide
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Alternative Names: 269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49d; Integrin alpha-4; Integrin alpha-IV; ITGA-IV; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 subunit alpha
• Entrez Gene ID: 3676