MRGPRX2 Polyclonal Antibody (NHP-AB277)

• This product is an antibody that was generated by immunizing rabbit against a peptide located in the C-Terminal cytoplasmic domain of MRGPRX2 (Human). It is used only in in vitro assays.

Detailed Product Description

• Introduction: MRGPRX2 probably involved in the function of nociceptive neurons. It may regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.
• Conjugate: None
• Applications: ELISA; IHC

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Chimpanzee; Gorilla; Human
• Immunogen: A peptide located in the C-Terminal cytoplasmic domain of MRGPRX2 (Human)

Product Property

• Purification: Immunoaffinity Chromatography
• Format: Liquid
• Concentration: 1 mg/mL
• Buffer: PBS, 0.1% sodium azide.
• Storage: Short term: 4˚C. Long term: Store at -20˚C. Avoid freeze-thaw cycles.

Target Information

• Clonality: Polyclonal
• Alternative Names: G protein-coupled receptor MRGX2; Mas-related G protein-coupled receptor G3; Mas-related G-protein coupled receptor member B10; Mas-related G-protein coupled receptor member X2; MAS-related GPR, member B10; MAS-related GPR, member X2
• Entrez Gene ID: 117194