Category:
Non-Human Primate (NHP) related Antibody Products
p21 Monoclonal Antibody (G2C2) (NHP-AB160)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing mouse against human recombinant protein. It is used only in in vitro assays.
Introduction:
Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.
Conjugate:
None
Antibody Isotype:
IgG1κ
Applications:
Flow Cytometry; IF; IHC-P; WB
Host Species:
Mouse
Species Reactivity:
Chimpanzee; Human; Monkey; Mouse; Rat
Immunogen:
Human recombinant protein
Purification:
Protein G affinity chromatography
Format:
Liquid
Concentration:
0.2 mg/mL
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Storage:
Store at 4⁰C.
Target:
p21
Clone:
G2C2
Clonality:
Monoclonal
Alternative Names:
CDK-interacting protein 1; CDK-interaction protein 1; CDNK1A; Cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A (P21); cyclin-dependent kinase inhibitor 1A (p21, Cip1); cyclin-dependent kinase inhibitor 1A variant 1; cyclin-dependent kinase inhibitor 1A variant 2; DNA synthesis inhibitor; MDA-6; melanoma differentiation associated protein 6; Melanoma differentiation-associated protein; Melanoma differentiation-associated protein 6; OTTHUMP00000016298; p21; p21; p21Cip1/Waf1; wild-type p53-activated fragment 1
Entrez Gene ID:
1026
Function:
P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.
- p21 Monoclonal Antibody (G2C2) (NHP-AB160) Data Sheet: Detailed information. datasheet
There are currently no customer reviews or questions for p21 Monoclonal Antibody (G2C2) (NHP-AB160). Click the button below to contact us or submit your feedback about this product.
Your research is unique, and we understand that standard products may not always fit. Our team of experts specializes in custom NHP sample collections. We can design a tailored protocol to meet your specific research requirements, including samples with unique anticoagulant types, customized volumes, or from specific disease models.
You may also be interested in…
Online Inquiry
For research use only. Not intended for any clinical use.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.