Category:
Non-Human Primate (NHP) related Antibody Products
PDE6A Polyclonal Antibody (NHP-AB416)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing rabbit against a peptide located in the N-Terminal region of PDE6A (Human). It is used only in in vitro assays.
Introduction:
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
Conjugate:
None
Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Gibbon; Gorilla; Hamster; Human; Monkey; Mouse; Rat
Immunogen:
A peptide located in the N-Terminal region of PDE6A (Human)
Purification:
Immunoaffinity Chromatography
Format:
Liquid
Concentration:
0.23 mg/mL
Buffer:
PBS, 0.1% sodium azide
Storage:
Short term: 4˚C. Long term: Store at -20˚C.
Clonality:
Polyclonal
Related Disease:
Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
Alternative Names:
cGMP phosphodiesterase alpha subunit (EC 3.1.4.35); PDE V-B1; phosphodiesterase 6A, cGMP-specific, rod, alpha; phosphodiesterase, cyclic GMP (rod receptor), alpha polypeptide; Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; unnamed protein product
Entrez Gene ID:
5145
- PDE6A Polyclonal Antibody (NHP-AB416) Data Sheet: Detailed information. datasheet
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