PDE6A Polyclonal Antibody (NHP-AB416)

• This product is an antibody that was generated by immunizing rabbit against a peptide located in the N-Terminal region of PDE6A (Human). It is used only in in vitro assays.

Detailed Product Description

• Introduction: This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
• Conjugate: None
• Applications: IHC

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Gibbon; Gorilla; Hamster; Human; Monkey; Mouse; Rat
• Immunogen: A peptide located in the N-Terminal region of PDE6A (Human)

Product Property

• Purification: Immunoaffinity Chromatography
• Format: Liquid
• Concentration: 0.23 mg/mL
• Buffer: PBS, 0.1% sodium azide
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Related Disease: Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
• Alternative Names: cGMP phosphodiesterase alpha subunit (EC 3.1.4.35); PDE V-B1; phosphodiesterase 6A, cGMP-specific, rod, alpha; phosphodiesterase, cyclic GMP (rod receptor), alpha polypeptide; Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; unnamed protein product
• Entrez Gene ID: 5145